Avemar pulvis, the active ingredient of the Avemar products, is made of fermented wheat germ. Wheat germ can be subjected to fermentation with Saccharomyces cerevisiae (baker's yeast) to yield the important benzoquinones: 2,6‑dimethoxy-benzoquinone (DMBQ) and 2-methoxy-benzoquinone. These benzoquinones are present in unfermented wheat germ as glycosides and the yeast glycosidase activity present during fermentation leads to release of the benzoquinones as aglycones. After fermentation the aqueous extract of wheat germ is decanted, and the product is spray-dried, homogenized, encapsulated, and formulated. The dried fermented wheat germ extract is standardized to contain methoxy-substituted benzoquinones (2-methoxy-benzoquinone and 2,6‑DMBQ) at a concentration of 0.04%.
Since the invention of Avemar pulvis significant research has been undertaken - not only in the laboratory, but in test animals and human cancer patients as well.