Paku S
MSC, a new benzoquinone-containing natural product with antimetastatic effect
Authors
Journal
Cancer Biotherapy and Radiopharmaceuticals
Release date
1999; 14(4):277-89.
Abstract/summary
An orally applicable fermentation product of wheat germ containing 0.04% substituted benzoquinone (MSC) has been invented by Hungarian chemists under the trade name of AVEMAR. Oral administration (3 g/kg body weight) of MSC enhances blastic transformation of splenic lymphocytes in mice. The same treatment shortens the survival time of skin grafts in a co-isogenic mouse skin transplantation model, pointing to the immune-reconstructive effect of MSC. A highly significant antimetastatic effect of MSC has been observed in three metastasis models (3LL-HH, B16, HCR-25).
Keywords
Content type
Pubmed
Original publication
Professional work place of the authors
- 1st Institute of Pathology and Experimental Cancer Research, Semmelweis University Budapest, Hungary
- 2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
- Central Food Research Institute, Budapest, Hungary
- Department of Biochemistry and Food Technology, Budapest Universty of Technology and Economics , Budapest, Hungary
A new benzoquinone-containing antimetastatic product
Authors
Journal
Orvosi Hetilap
Release date
1998; 139(48):2893-7.
Abstract/summary
An orally applicable fermentation product of wheat germ containing 0.04% substituted benzoquinone (MSC) was invented by Hungarian chemists under the trade--name of AVEMAR. The following biological effects of this product were observed. Oral administration (3 g/kg body weight) of MSC enhances blastic transformation of splenic lymphocytes of mice. The same treatment shortens the survival time of skin grafts in co-isogenic mouse skin transplantation model, which points to immune-reconstructive effect of MSC.
Content type
Pubmed
Original publication
Professional work place of the authors
- 1st Institute of Pathology and Experimental Cancer Research, Semmelweis University Budapest, Hungary
- 2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
- Central Food Research Institute, Budapest, Hungary
- Department of Biochemistry and Food Technology, Budapest Universty of Technology and Economics , Budapest, Hungary
Effect of Avemar and Avemar + vitamin C on tumor growth and metastasis in experimental animals
Authors
Journal
Anticancer Research Journal
Release date
1998; 18(4A):2353-8.
Abstract/summary
Because of the observed immunostimulatory actions of a new fermented wheat germ extract--with standardized benzoquinone composition--we have investigated the eventual tumor growth- and metastasis-inhibiting effects of this preparation (Avemar) applied alone or in combination with vitamin C. Tumor models of different origin [a highly metastatic variant of the Lewis lung carcinoma (3LL-HH), B16 melanoma, a rat nephroblastoma (RWT-M) and a human colon carcinoma xenograft (HCR25)]--kept in artificially immunosuppressed mice were applied.
