MSC
Fermented wheat germ extract in the supportive therapy of colorectal cancer
Authors
Journal
Orvosi Hetilap
Release date
2005; 146(37):1925-31.
Abstract/summary
The role of the product in the treatment of colorectal cancer is reviewed in the light of experimental and clinical results to date. The fermented wheat germ extract (code name: MSC, trade name: Avemar) registered as a dietary food for special medical purposes for cancer patients to complement the active oncotherapy, exerted a growth inhibitory effect in HCR-25 human colon carcinoma xenograft, and had a synergistic effect with 5-FU in mouse C-38 colorectal carcinoma. The product is capable of chemoprevention of colon carcinoma in F-344 rats.
Keywords
Content type
Pubmed
Original publication
MSC, a new benzoquinone-containing natural product with antimetastatic effect
Authors
Journal
Cancer Biotherapy and Radiopharmaceuticals
Release date
1999; 14(4):277-89.
Abstract/summary
An orally applicable fermentation product of wheat germ containing 0.04% substituted benzoquinone (MSC) has been invented by Hungarian chemists under the trade name of AVEMAR. Oral administration (3 g/kg body weight) of MSC enhances blastic transformation of splenic lymphocytes in mice. The same treatment shortens the survival time of skin grafts in a co-isogenic mouse skin transplantation model, pointing to the immune-reconstructive effect of MSC. A highly significant antimetastatic effect of MSC has been observed in three metastasis models (3LL-HH, B16, HCR-25).
Keywords
Content type
Pubmed
Original publication
Professional work place of the authors
- 1st Institute of Pathology and Experimental Cancer Research, Semmelweis University Budapest, Hungary
- 2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
- Central Food Research Institute, Budapest, Hungary
- Department of Biochemistry and Food Technology, Budapest Universty of Technology and Economics , Budapest, Hungary
Fermented wheat germ extract induces apoptosis and downregulation of major histocompatibility complex class I proteins in tumor T and B cell lines
Authors
Journal
International Journal of Oncology
Release date
2002; 20(3):563-70.
Abstract/summary
The fermented wheat germ extract (code name: MSC, trade name: Avemar), with standardized benzoquinone content has been shown to inhibit tumor propagation and metastases formation in vivo. The aim of this study was to understand the molecular and cellular mechanisms of the anti-tumor effect of MSC. Therefore, we have designed in vitro model experiments using T and B tumor lymphocytic cell lines.
Keywords
Content type
Pubmed
Original publication
Professional work place of the authors
- Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary
- Central Food Research Institute, Budapest, Hungary
- Department of Biochemistry and Food Technology, Budapest Universty of Technology and Economics , Budapest, Hungary
- Department of Medicine 'B', Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel
- Lymphocyte Signal Transduction Laboratory, Institute of Genetics and Cytokine Group, Institute of Biochemistry, Szeged, Hungary
- National Institute of Oncology, Budapest, Hungary
