MSC

Fermented wheat germ extract in the supportive therapy of colorectal cancer


Authors
Journal
Orvosi Hetilap
Release date
2005; 146(37):1925-31.
Abstract/summary

The role of the product in the treatment of colorectal cancer is reviewed in the light of experimental and clinical results to date. The fermented wheat germ extract (code name: MSC, trade name: Avemar) registered as a dietary food for special medical purposes for cancer patients to complement the active oncotherapy, exerted a growth inhibitory effect in HCR-25 human colon carcinoma xenograft, and had a synergistic effect with 5-FU in mouse C-38 colorectal carcinoma. The product is capable of chemoprevention of colon carcinoma in F-344 rats.

Keywords
Content type
Pubmed
Original publication

MSC, a new benzoquinone-containing natural product with antimetastatic effect


Authors
Journal
Cancer Biotherapy and Radiopharmaceuticals
Release date
1999; 14(4):277-89.
Abstract/summary

An orally applicable fermentation product of wheat germ containing 0.04% substituted benzoquinone (MSC) has been invented by Hungarian chemists under the trade name of AVEMAR. Oral administration (3 g/kg body weight) of MSC enhances blastic transformation of splenic lymphocytes in mice. The same treatment shortens the survival time of skin grafts in a co-isogenic mouse skin transplantation model, pointing to the immune-reconstructive effect of MSC. A highly significant antimetastatic effect of MSC has been observed in three metastasis models (3LL-HH, B16, HCR-25).

Keywords
Content type
Pubmed
Original publication
Professional work place of the authors

Fermented wheat germ extract induces apoptosis and downregulation of major histocompatibility complex class I proteins in tumor T and B cell lines


Authors
Journal
International Journal of Oncology
Release date
2002; 20(3):563-70.
Abstract/summary

The fermented wheat germ extract (code name: MSC, trade name: Avemar), with standardized benzoquinone content has been shown to inhibit tumor propagation and metastases formation in vivo. The aim of this study was to understand the molecular and cellular mechanisms of the anti-tumor effect of MSC. Therefore, we have designed in vitro model experiments using T and B tumor lymphocytic cell lines.

Keywords
Content type
Pubmed
Original publication
Professional work place of the authors