cytokine

Synergistic effect of Avemar on proinflammatory cytokine production and Ras-mediated cell activation


Authors
Journal
Annals of the New York Academy of Sciences
Release date
2005; 1051:515-28.
Abstract/summary

Macrophages activated by lipopolysaccharide and/or phorbol esters exhibited high sensitivity to Avemar, a fermented wheat germ extract. Avemar synergized with lipopolysaccharide and PMA in the induction of the transcription of cytokine genes and release of inflammatory cytokines. At higher concentrations the preparation had a significant negative effect on the proliferation and survival of activated myeloid cell types. Avemar treatment induced the synthesis of ICAM-1 and synergized with the ICAM-inducing effect of TNF, but had no effect on VCAM-1 expression on microvascular endothelial cells.

Keywords
Content type
Pubmed
Original publication
Professional work place of the authors