apoptosis

Fermented wheat germ extract in the supportive therapy of colorectal cancer


Authors
Journal
Orvosi Hetilap
Release date
2005; 146(37):1925-31.
Abstract/summary

The role of the product in the treatment of colorectal cancer is reviewed in the light of experimental and clinical results to date. The fermented wheat germ extract (code name: MSC, trade name: Avemar) registered as a dietary food for special medical purposes for cancer patients to complement the active oncotherapy, exerted a growth inhibitory effect in HCR-25 human colon carcinoma xenograft, and had a synergistic effect with 5-FU in mouse C-38 colorectal carcinoma. The product is capable of chemoprevention of colon carcinoma in F-344 rats.

Keywords
Content type
Pubmed
Original publication

The efficacy of tamoxifen in estrogen receptor-positive breast cancer cells is enhanced by a medical nutriment


Authors
Journal
Cancer Biotherapy and Radiopharmaceuticals
Release date
2004; 19(6):746-753
Abstract/summary

Avemar, a fermented wheat germ extract, has been applied in the supplementary therapy of human cancers. Because tamoxifen is commonly used in the therapy of ER+ breast cancer, in this study the combined effect of tamoxifen and Avemar treatment was investigated on MCF-7 breast cancer cells, in order to detect a possible agonistic or antagonistic action.

Keywords
Content type
Pubmed
Original publication
Professional work place of the authors

Avemar, a nontoxic fermented wheat germ extract, attenuates the growth of sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells through induction of apoptosis


Authors
Journal
Oncology Reports
Release date
2009; Volume 21:(3):787-91
Abstract/summary

Avemar (MSC) is a nontoxic fermented wheat germ extract, which has been shown to significantly improve the survival rate in patients suffering from various malignancies. We investigated its effects in sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells. After 48 and 72 h of incubation, Avemar inhibited the growth of sensitive H9 cells with IC50 values of 290 and 200 microg/ml, whereas the growth of 5-FdUrd/Ara-C cross-resistant H9 cells was attenuated with IC50 values of 180 and 145 microg/ml, respectively.

Keywords
Content type
Pubmed
Original publication
Professional work place of the authors

Avemar, a nontoxic fermented wheat germ extract, induces apoptosis and inhibits ribonucleotide reductase in human HL-60 promyelocytic leukemia cells


Authors
Journal
Cancer Letters
Release date
2007; 250(2):323-8
Abstract/summary

Avemar (MSC) is a nontoxic fermented wheat germ extract demonstrated to significantly improve the survival rate in patients suffering from various malignancies. We investigated its effects in human HL-60 promyelocytic leukemia cells. After 24, 48, and 72 h of incubation, Avemar inhibited the growth of HL-60 cells with IC50 values of 400, 190, and 160 microg/ml, respectively. Incubation with MSC caused dose-dependent induction of apoptosis in up to 85% of tumor cells. In addition, Avemar attenuated the progression from G2-M to G0-G1 phase of

Keywords
Content type
Pubmed
Original publication
Professional work place of the authors

Immunologic and biochemical effects of the fermented wheat germ extract Avemar


Authors
Journal
Experimental Biology and Medicine (Maywood)
Release date
2005; 230(2):144-9.
Abstract/summary

Avemar (MSC) is a nontoxic fermented wheat germ extract demonstrated to have antitumor effects. Avemar has the potential to significantly improve the survival rate in patients suffering from malignant colon tumors. We studied its effects in the HT-29 human colon carcinoma cell line. Avemar had an inhibiting effect on colonies of HT-29 cells with an IC50 value of 118 microg/ml (7 days of incubation); this value could be decreased to 100 and 75 microg/ml in the presence of vitamin C.

Keywords
Content type
Pubmed
Original publication
Professional work place of the authors

Fermented wheat germ extract induces apoptosis and downregulation of major histocompatibility complex class I proteins in tumor T and B cell lines


Authors
Journal
International Journal of Oncology
Release date
2002; 20(3):563-70.
Abstract/summary

The fermented wheat germ extract (code name: MSC, trade name: Avemar), with standardized benzoquinone content has been shown to inhibit tumor propagation and metastases formation in vivo. The aim of this study was to understand the molecular and cellular mechanisms of the anti-tumor effect of MSC. Therefore, we have designed in vitro model experiments using T and B tumor lymphocytic cell lines.

Keywords
Content type
Pubmed
Original publication
Professional work place of the authors