Immune response

It has been shown that while Avemar increases cellular immune response, it also decreases the humoral immune response therefore acts as an immuno-modulating agent.

Intensive chemotherapy might cause episodes with high fever caused by the insufficient number of white blood cells resulting from the treatment. A study has shown that these episodes were less frequent in pediatric cancer patients who received Avemar. This study confirmed the clinical relevance of bone marrow protection assessed in an experimental setting.

COX-1 and COX-2 enzymes

These enzymes play a crucial role in the immune system, and the pharmacological inhibition of COX can provide relief from the symptoms of inflammation and pain. Avemar non-selectively inhibits both of these enzymes and this feature may partly explain its anti-inflammatory activities against adjuvant arthritis in rats and rheumatoid arthritis in humans.