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Increase in haemopoiesis
The effect of Avemar on the regeneration of haemopoiesis was examined in animal experiments where a sublethal dosage of radiation or cyclophosphamide was used to provoke bone marrow impairment. On the seventh day following irradiation, the thrombocyte-count started to rise and returned to normal levels by the 21st day. No significant difference was observed in the leukocyte-count, as compared with the control group. After treatment with cyclophosphamide, thrombocyte-regener-ation improved due to the administration of Avemar; it also had a similar effect on the reticulocyte-count [14]. The results support the clinical evidence gathered over the past few years suggest-ing that Avemar has no haematologic side-effects, and that, it reduces the haematological side-effects of radiotherapy and chemotherapy.
Conclusions: This agrees with clinical evidence suggesting that Avemar has no haematology-related side effects.
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