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The combination of Avemar with cytostatics
A similar type of cancer-cell implantation was used in experiments investigating the respons of mouse-38 colon carcinoma to a combination of 5-fluoro-uracil (5-FU) i. p. and Avemar p. o. treatment. A signi-ficant reduction in number of liver metastases was observed when compared to the control group receiving 5-FU alone. A combination treatment of DTIC (dacarbazin) i. p. + Avemar p. o. resulted in a complete eradication of lung metastases in mice with B-16 melanoma.
This demonstrates a synergism between the first line drug for melanoma and Avemar when acting on a tumor resembling human malignant melanoma [5].
Another important finding revealed by the animal tests outlined above was that, while Avemar has no substantial influence on the effect of cytostatics on the primary tumor, it has a marked potentiating effect in inhibiting metastasis formation [2].
Conclusions: The synergistic effect expressed through Avemar's inhibition of metastases deserves attention, though its inhibition of primary tumour growth is also noteworthy.
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