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Increasing the production of TNF-Alpha (tumor necrosis factor Alpha)

TNF-Alpha, one of the major cytokines capable of killing tumour cells, is produced by activated macrophages. Avemar increases the activated macrophages' production of TNF-Alpha. TNF-Alpha directly stimulates apoptosis and is capable of inhibiting angiogenesis in tumour cells.

Conclusions: The inhibition of tumour angiogenesis in early cancer phases can contribute to the prevention of metastases - something observed in clinical tests as well.

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»	Review 1 Immunological effects
»	Review 2 The effects of avemar on the metabolism of cancer cells
»	Review 3 The effects of avemar on the escape/survival strategies of cancer cells

»	Immunmodulatory effect

»	Induction of apoptosis

»	Effect on glucose/nucleic acid metabolism

»	Selective inhibition of MHC-I (main histocompatibility-I) antigen expression on cell surface

«	Increasing the production of TNF-Alpha (tumor necrosis factor Alpha)

»	Increase in the ICAM-I (intracellular adhesion molecule)( CD 45) level