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Immunmodulatory effect
a) Increase of blastic transformation:
Avemar increases the degree of blastic transformation, as demonstrated by tests in which 3H thymidin incorporation was induced with Concavalin A.
b) Restoration of impaired immune response/Implantation of skin allograft:
A skin allograft was implanted from a different mouse species into thymectomized mice. Although the rejection time in mice treated with Avemar was longer in the thymectomized mice than in the non-thymectomized ones, it was still shorter than that in the control mice. Nevertheless, this demonstrates Avemar's ability to repair damaged immune systems and improve the functioning of cellular immune response, an effect which derives from its stimulatory effect on the maturation and differentiation of bone marrow lymphocytes.
Conclusions: Avemar's stimulatory effect on cellular immune response plays an important role in its clinical effectiveness.
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